Michael J Palladino Selected Research

Triose-Phosphate Isomerase (Triosephosphate Isomerase)

1/2022	Itavastatin and resveratrol increase triosephosphate isomerase protein in a newly identified variant of TPI deficiency.
1/2021	Identification of protein quality control regulators using a Drosophila model of TPI deficiency.
1/2019	Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo.
3/2016	Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.
12/2010	Hsp70- and Hsp90-mediated proteasomal degradation underlies TPI sugarkill pathogenesis in Drosophila.

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Michael J Palladino Research Topics

Disease

5	Hemolytic Anemia 01/2022 - 06/2008
4	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 01/2019 - 01/2011
3	Metabolic Diseases (Metabolic Disease) 01/2019 - 07/2013
3	Epilepsy (Aura) 01/2019 - 02/2003
3	Seizures (Absence Seizure) 01/2019 - 09/2016
2	Neurologic Manifestations (Neurological Manifestations) 01/2019 - 03/2016
2	Infections 12/2016 - 12/2010
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Intellectual Disability (Idiocy) 01/2019
1	Huntington Disease (Huntington's Disease) 12/2018
1	Hepatitis C 11/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2018
1	Inflammation (Inflammations) 12/2016
1	Sepsis (Septicemia) 12/2016
1	Disease Progression 09/2016
1	Cardiomyopathies (Cardiomyopathy) 03/2016
1	Hypoxia (Hypoxemia) 10/2015
1	Hyperoxia 07/2012
1	Migraine with Aura (Familial Hemiplegic Migraine) 09/2009
1	Dystonia 12 09/2009
1	Carcinogenesis 01/2007

Drug/Important Bio-Agent (IBA)

5	Triose-Phosphate Isomerase (Triosephosphate Isomerase)IBA 01/2022 - 12/2010
4	Proteins (Proteins, Gene)FDA Link 11/2018 - 06/2008
3	EnzymesIBA 01/2019 - 07/2012
3	Adenosine Triphosphate (ATP)IBA 12/2016 - 10/2015
2	Adenosine Triphosphatases (ATPase)IBA 09/2009 - 01/2007
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	polyglutamineIBA 12/2018
1	Amyloid (Amyloid Fibrils)IBA 12/2018
1	Transcription Factors (Transcription Factor)IBA 11/2018
1	MetalsIBA 11/2018
1	ZincIBA 11/2018
1	ElementsIBA 11/2018
1	PotassiumIBA 11/2018
1	Potassium Channels (Potassium Channel)IBA 11/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 12/2016
1	Linezolid (Zyvox)FDA Link 12/2016
1	Antimicrobial PeptidesIBA 12/2016
1	Adenosine Monophosphate (AMP)IBA 12/2016
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2016
1	Glucose (Dextrose)FDA LinkGeneric 12/2016
1	Insulin (Novolin)FDA Link 12/2016
1	Pyruvic Acid (Pyruvate)IBA 12/2016
1	salicylhydroxamic acid (SHAM)IBA 12/2016
1	KATP ChannelsIBA 09/2016
1	Pharmaceutical PreparationsIBA 09/2016
1	PKC-3 proteinIBA 10/2015
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2015
1	Aurora KinasesIBA 10/2015
1	Mitochondrial DNA (mtDNA)IBA 01/2011
1	Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)IBA 02/2003

Therapy/Procedure

2	Diet Therapy (Therapy, Diet) 01/2019 - 09/2016
2	Therapeutics 01/2019 - 09/2016
1	Ketogenic Diet 09/2016